A Test for Dose Dependency of Drug Efficacy through Dose Escalation Design
نویسندگان
چکیده
منابع مشابه
Dose escalation of a curcuminoid formulation
BACKGROUND Curcumin is the major yellow pigment extracted from turmeric, a commonly-used spice in India and Southeast Asia that has broad anticarcinogenic and cancer chemopreventive potential. However, few systematic studies of curcumin's pharmacology and toxicology in humans have been performed. METHODS A dose escalation study was conducted to determine the maximum tolerated dose and safety ...
متن کاملIndividualized Tamoxifen Dose Escalation-Letter.
In a recent commentary (1), Hertz and Rae have put the relevance of pharmacokinetically guided dosing of tamoxifen into perspective. We appreciate this effort and fully agree that more evidence is required to refine the relationship between exposure to the active tamoxifen metabolite endoxifen and clinical outcome parameters. On the basis of the relatively long survival of adjuvantly treated br...
متن کاملAdaptive Designs for Dose Escalation Studies
In Phase I dose escalation studies the 3+3 design is a commonly used method. We suggest a modification of this method to include a parametric model and the concepts of optimal design theory, with the aim of improving this method. The performance of the original and the new approach are investigated by simulations.
متن کاملinvestigating the feasibility of a proposed model for geometric design of deployable arch structures
deployable scissor type structures are composed of the so-called scissor-like elements (sles), which are connected to each other at an intermediate point through a pivotal connection and allow them to be folded into a compact bundle for storage or transport. several sles are connected to each other in order to form units with regular polygonal plan views. the sides and radii of the polygons are...
Using SAS to Assess Dose Proportionality in Dose Escalation Studies
Dose escalation studies provide a good opportunity to assess the linearity of PK parameters. This paper describes hypothesis testing and confidence interval (C.I.) methods for assessing dose proportionality based on linear regression and weighted least squares (WLS) linear regression. SAS® code is presented using an example study and AUCinf data.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Biometrics
سال: 1991
ISSN: 0918-4430,2185-6494
DOI: 10.5691/jjb.12.85